Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Chronic spontaneous urticaria is an idiopathic syndrome defined by recurring itch, hives, or angioedema (or a combination of these symptoms) for more than 6 weeks. Remibrutinib, an oral, highly ...

Decades of strict sentencing laws, the racially motivated “War on Drugs,” and simultaneous erosion of community mental health and social services have contributed to the American public health ...

Panel A is a map of the communes in Nha Trang showing the trial-group assignment in each commune (no vaccination, 0p+1, 1p+1, 2p+1, or 3p+0). Panel B shows the percentages of infants (children 4 ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Primary central nervous system (CNS) vasculitis is a rare, frequently misdiagnosed condition that affects the brain and spinal cord and is characterized by a variety of neurologic symptoms at ...

EBV is one of the most successful viruses, infecting over 90 percent of humans and persisting for the lifetime of the person. EBV is closely related to viruses present in Old World nonhuman ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

This review article presents two true-life clinical vignettes that illustrate how digital health technology can aid providers caring for patients with epilepsy. Specific information that would ...

Neutrophils constitute the main infiltrating cell type in Behçet’s syndrome lesions. By producing excessive levels of reactive oxygen species and releasing neutrophil extracellular traps ...

Primary biliary cholangitis is a rare, chronic cholestatic liver disease characterized by the destruction of interlobular bile ducts, leading to cholestasis and liver fibrosis. Whether elafibranor ...