Supported by grants from Région des Pays de la Loire (project “EryCan,” Biogenouest), Agence Nationale de la Recherche (ANR-15-CE17-0021-04 “GenRED,” ANR-20-CE14-0043-01 “SplicHypoxia ...

In the peripheral airways of patients with chronic obstructive pulmonary disease, as compared with normal peripheral airways, there is airflow limitation due to a variable mixture of loss of ...

Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated ...

Chronic spontaneous urticaria is an idiopathic syndrome defined by recurring itch, hives, or angioedema (or a combination of these symptoms) for more than 6 weeks. Remibrutinib, an oral, highly ...

Following rigorous peer, editorial, and statistical review, the New England Journal of Medicine (NEJM) editorial team will either decline a manuscript or express interest in publishing it (after ...

Endovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect of EVT for occlusion of medium or distal vessels is unclear. We randomly assigned ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Dr. Mallory C. Mandel (Pediatrics): A 16-year-old girl was admitted to this hospital because of abdominal pain. The patient had been in her usual state of health until 4 weeks before the current ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Most moderate-to-late–preterm infants need nutritional support after birth pending a sufficient supply and intake of mother’s breast milk; however, evidence for the best strategy for nutrition ...

The mechanisms involved in the development of cardiovascular disease in persons with type 1 diabetes are shown. Data from randomized, controlled trials examining the effect of statins on ...

Transthyretin amyloid cardiomyopathy is characterized by the deposition of misfolded monomeric transthyretin (TTR) in the heart. Acoramidis is a high-affinity TTR stabilizer that acts to inhibit ...