Background and aims Human telomerase reverse transcriptase (hTERT) plays an important role in cancer invasion, but the relevant mechanism is not well known. This study aims to investigate the role and ...

Objective Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic, proinflammatory ...

Introduction There are approximately 15,000 new diagnoses of oesophageal and gastric cancer every year, in the UK (Cancer Research UK, 2022). Timely detection of cancer remains a key marker in ...

Hepatic dendritic cells (DC) unquestionably play important roles in the induction and regulation of immune responses. Due to their paucity, functional characterisation of these important antigen ...

The gut microbiota has been implicated in cancer and shown to modulate anticancer drug efficacy. Altered gut microbiota is associated with resistance to chemo drugs or immune checkpoint inhibitors ...

These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) ...

Background The development of IBD is known to involve early immunological alterations, but our understanding of the changes ...

Introduction Crohn’s disease (CD) is a chronic inflammatory bowel disease that can affect any part of the gastro- intestinal tract. The natural history of CD is difficult to predict. In some patients, ...

Background Biologic therapies such as anti-tumour necrosis factor alpha (anti-TNF) are common approaches used in the management of ulcerative colitis (UC), but they are limited by varying therapeutic ...

Randomised controlled trials (RCTs) have shown that computer-aided detection (CADe) can significantly improve adenoma detection rates (ADRs). In contrast, implementation studies did not show ADR ...

Introduction The Covid-19 pandemic severely disrupted healthcare services. In March 2020, the government announced the ‘Everyone In’ initiative to support everyone rough sleeping or in accommodation ...

Transcription factors of the family p53 have emerged as an important set of tumour suppressors, able to regulate various cell functions like cell cycle arrest, differentiation, DNA repair, apoptosis ...