Will having python installed without some type of virtual environment effect anything that is related to the Mac OS python, specially when installing pip packages?

Python Development Master taps new features in Python to manage a project’s packages without the overhead imposed by a virtual environment.

Take advantage of BeeWare Briefcase to make Python programs that are a snap to deploy and easy to redistribute ...

Devs unknowingly use “malicious” modules snuck into official Python repository Code packages available in PyPI contained modified installation scripts.