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To run 32-bit applications on 64-bit Windows, right-click the application and go to Properties > Compatibility. Select Run this program in compatibility mode for and choose the version in which ...
However, Microsoft allows the desktop version of the 64-bit Explorer application to process Web pages in 32-bit compatibility mode to accommodate older browser add-ons.
Microsoft has sent a statement to Neowin about how Internet Explorer 10 will run in the 64-bit and the 32-bit version of Windows 8, in both the desktop and "Modern" user interfaces.
Identifying your system type is also important when upgrading. If you're running a 32-bit version of Windows, upgrading to 64-bit can help unlock the full potential of your computer.
VirtualBox is flexible enough to handle many types of 32-bit and 64-bit configurations. If you need to run a 32-bit version of XP in a 64-bit host, you can do that without any problems.
A few editions of 64-bit Windows 7 provide a Windows XP Mode that solves some backward-compatibility problems, but it isn’t a universal panacea.