It's relatively accessible compared to 3D animation (see below) and it allows a lot of flexibility since almost any style of art can be used. There are various 2D animation techniques.

However, in a short compilation of nearly 50 of these Disney classics, viewers can really tell the difference between the still backdrops and 2D movements of Snow White and the pop of 3D animation ...

The Transformers franchise often shifted between 2D and 3D animation. The original show and corresponding movie used the hand-drawn style, but the 1990s saw the birth of Beast Wars and Beast Machines.